Differences Between Alpha-Fetoprotein (AFP) and Prothrombin Induced by Vitamin K Absence or antagonist II (PIVKA-II) Values as Early Detection Method for Hepatocellular Carcinoma (HCC) and Cirrhosis
نویسندگان
چکیده
منابع مشابه
performance of protein induced by vitamin k absence or antagonist-ii (pivka-ii) for hepatocellular carcinoma screening in chinese population
conclusions pivka-ii was as efficient as afp when used as a single marker for hcc screening and the combination of two biomarkers gave a better performance. results the sensitivity and specificity of pivka-ii were 74.6% and 67.8% at a cutoff of 40 mau/ml and 64.2% and 89.7% at a cutoff of 200 mau/ml. the sensitivity and specificity of afp were 76.7% and 65.0% at a cutoff of 20 ng/ml and 60.4% a...
متن کاملPerformance of Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) for Hepatocellular Carcinoma Screening in Chinese Population
BACKGROUND Alpha-fetoprotein (AFP) has long been used as an effective biomarker for hepatocellular carcinoma (HCC) screening; however, not all HCC patients can be detected with an elevated AFP level, especially in early HCC patients. Protein Induced by vitamin K absence or antagonist-II (PIVKA-II) is another serum biomarker linked to HCC; however, sensitivity and specificity remain controversia...
متن کاملUsefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma
Alpha-fetoprotein (AFP), Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). This study compared the diagnostic values of AFP, AFP-L3, and PIVKA-II individually and in combination to find the best biomarker or biomarker panel.Seventy...
متن کاملClinical Significance of AFP and PIVKA-II Responses for Monitoring Treatment Outcomes and Predicting Prognosis in Patients with Hepatocellular Carcinoma
AIM Recently, the utility of tumor markers in the hepatocellular carcinoma (HCC) field has received a good deal of attention. Here, we review and summarize the results of studies on the roles played by the α -fetoprotein (AFP) and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) responses in terms of the monitoring of outcomes and prediction of prognosis after various...
متن کاملHepatocellular carcinoma (HCC) and diagnostic significance of A-fetoprotein (AFP).
BACKGROUND Alpha-fetoprotein (alpha-fetoprotein, AFP) is a Glycoprotein, belonging to the intriguing class of onco-development protein. Generally designated as tumour marker, AFP is recognized as an important blood component, having specific diagnostic utilities Elevation of its level up to pathological range in adults correlate with the appearance of several malignant and chronic conditions, s...
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ژورنال
عنوان ژورنال: The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
سال: 2018
ISSN: 2302-8181,1411-4801
DOI: 10.24871/1932018153-157